|Exposing the LASIK Scam
|Treating LASIK induced dry eye with patients' own blood
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|Author:||Broken Eyes [ Sat Jun 30, 2007 9:02 pm ]|
|Post subject:||Treating LASIK induced dry eye with patients' own blood|
J Refract Surg. 2007 Jun;23(6):617-9.
Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma.
Alio JL, Pastor S, Ruiz-Colecha J, Rodriguez A, Artola A.
Department of Cornea and Refractive Surgery, VISSUM Instituto Oftalmol?gico de Alicante, Spain. firstname.lastname@example.org
PURPOSE: To ascertain the usefulness of platelet-rich plasma in the treatment of patients suffering from symptomatic ocular surface syndrome following LASIK.
METHODS: Twenty-six eyes (9 women and 4 men) affected by symptomatic ocular surface syndrome were treated with topical eye drops of autologous platelet-rich plasma and results were reported at 4 weeks. Topical platelet-rich plasma was prepared from total blood and enriched in platelets by centrifugation.
RESULTS: Eighty-five percent of patients experienced significant improvement of symptoms; best spectacle-corrected visual acuity increased 1 to 2 lines in 54%; fluorescein staining analysis showed a 69% full fluorescein disappearance; and tear break-up time increased > 2 seconds in 46%. Only one patient developed intolerance to platelet-rich plasma after 4 weeks.
CONCLUSIONS: Autologous platelet-rich plasma was effective in the treatment of patients with ocular surface syndrome following LASIK, with symptoms generally relieved and a positive effect on punctate keratitis.
From the full text:
Laser in situ keratomileusis (LASIK), although highly successful,1 has a common side effect? ocular surface syndrome. This complex multifactorial entity distresses patients and physicians, and is characterized by the following symptoms: dry eye, micropunctate keratitis, decreased and unstable tear fi lm, and decreased best spectacle-corrected visual acuity (BSCVA) and visual quality. Ocular surface syndrome has a neurotrophic etiology, is long lasting, and is difficult to treat. A main function of the ocular nerves often damaged during LASIK is the regulation of secretion activities of the lacrimal and meibomian glands. Their damage causes neurotrophic epitheliopathy and affects tear composition.2 All lipidic, aqueous, and mucus components of tears are involved in the quality of the tear film, and any alteration can affect the ocular surface. When a deficiency is present on the aqueous phase of the tear film, the risk of infection by pathogens increases. A decrease in the quantity or quality of the mucus associated with goblet cells of the conjunctiva decreases tear stability. The same is observed when alteration of the lipid composition of tears affects the tears? evaporation control.3 An abnormal lid surface function and epitheliopathy may also affect the ocular surface. Finally, an alteration of the normal microvillus on the ocular surface may present difficulties in the adherence of the tear film to the epithelial surface.4
Blood drawn from patients was collected in 10-mL sterile tubes containing 1 mL sodium citrate acting as an anticoagulant. Enrichment of platelets in the plasma fraction (upper fraction) was achieved by centrifugation of total blood at optimal conditions. Platelets were enriched 2 to 2.5 times, according to quantitation performed through a coulter device. Under these conditions of centrifugation, leukocytes were dragged to the bottom of the tube, and proteins and platelets remained in the upper fraction, enriching the plasma. Depending on the patient?s hematocrit, the plasma fraction could vary from 25% to 50% of the total blood. Ninety percent of plasma obtained after centrifugation was collected. Generally, 24 to 40 mL of platelet-rich plasma were obtained from 100 mL of total blood. Patients were treated with platelet-rich plasma for a minimum of 1 month. The eye drop applicator was kept at 4? C for a maximum of 7 days, and the remaining vials were stored at -20?C for a maximum of 3 months. Platelet-rich plasma was prepared in optimal sterile conditions under a vented sterile fume hood.
Dry eye symptoms are common after LASIK as a result of corneal nerve damage during flap performance and alteration of the tear film volume and composition.4
|Author:||RaginFro [ Sat Nov 03, 2007 3:30 am ]|
I take it that this treats the symptoms, but it's not a "cure", right?
What happens when patients stop the treatment? Does the dry eye syndrome return?
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