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 Post subject: Keratocytes' Density Remains Low After Refractive Surgery
PostPosted: Sat Jun 09, 2007 4:50 pm 
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Cataract & Refractive Surgery Today
June, 2007

http://www.crstoday.com/Pages/News.php

Keratocytes' Density Remains Low After Refractive Surgery

According to a paper presented this month at the 6th International Congress on Advanced Surface Ablation and SBK, keratocytes' density decreases substantially in the anterior stroma of refractive surgery patients during the first postoperative year and remains low for several years.1

William M. Bourne, MD, from the Mayo Clinic College of Medicine in Rochester, Minnesota, performed confocal microscopy on 34 eyes of 23 patients who underwent PRK or LASIK. At 7 years postoperatively, the density of keratocytes in the anterior stroma of PRK patients had dropped from 45,000 to 33,000 cells/mm?, a total decrease of approximately 28%. He found a similar decrease (29%) in LASIK patients, whose keratocytes' density dropped from approximately 49,000 cells/mm? preoperatively to approximately 35,000 cells/mm? at 7 years postoperatively.

Because keratocytes secrete the collagen and proteoglycan necessary for the long-term maintenance of corneal clarity and curvature, the loss of these cells after refractive surgery may have long-term consequences for patients' corneal health, said Dr. Bourne. "We feel this possibility is unlikely, but cannot be ruled out," he added.

1. Bourne WM. The effect of PRK and LASIK on corneal keratocytes. Paper presented at: The 6th International Congress on Advanced Surface Ablation and SBK; May 5, 2007; Fort Lauderdale, FL.

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PostPosted: Sat Sep 22, 2007 8:51 pm 
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http://www.crstoday.com/PDF%20Articles/ ... 907_12.php

Cataract & Refractive Surgery Today
September, 2007

The Effect of PRK and LASIK on Corneal Keratocytes

Quote:
Keratocytes are specialized cells that secrete the collagen and proteoglycans needed to maintain the clarity and curvature of the cornea. Research has shown that the anterior 10% of the stroma?the layer of tissue that is ablated during PRK and included in a LASIK flap?contains the greatest density of corneal keratocytes.2 Because the minimum number of keratocytes needed to maintain the corneal stroma is unknown, the destruction of these cells during cornea-based refractive surgery may have long-term consequences for patients' corneal health.


Quote:
This study showed that the density of keratocytes in the anterior corneal stroma decreases substantially during the first year after PRK and LASIK, and their number remains reduced for at least 7 years. If the number of keratocytes remaining after these procedures is insufficient for long-term stromal maintenance, then changes in corneal clarity or curvature might be expected to develop many years after either procedure.

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"The price good men pay for indifference to public affairs is to be ruled by evil men." Plato


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